SAN :: First In Sports Nutrition

What is Sesamin?
Sesamin is a naturally occurring lignan that is present in pure sesame oil. For your information, a lignan is broadly considered an antioxidant that is present in unfiltered and unrefined seeds of sesame, pumpkin and flax as well as many other foods. Besides being a strong antioxidant, sesamin has shown great promise as a lipid oxidizer as well as to support anti-inflammatory action. Its main mechanism for fatty acid oxidation (fat burning) is triggered by the enzyme known as PPAR-alpha. PPAR-alpha (Peroxisome Proliferator-Activator Receptor Alpha) is documented to exist in muscle, the liver and adipose tissue (fat). Sesamin being a strong activator of this enzyme (PPAR-alpha) is therefore involved in the oxidation of fatty acids while simultaneously decreasing lipogenesis. In other words, PPAR-alpha activation is directly correlated with increasing fat burning in muscle tissue. Which is a good thing!!!

Sesamin and Insulin Sensitivity
Due to sesamin’s strong beta-oxidizing properties the substance can also affect leptin levels and thus restores insulin sensitivity in obese rodents†. Insulin sensitivity is often impaired in those whose body fat levels exceed 15% and higher. In more simple terms, by providing the necessary substrate; sesamin is believed to act as a thermostat of sorts that can regulate leptin as well as insulin levels from within the body keeping both in optimal balance.

Sesamin and Ketosis
Sesamin is a welcomed addition for those who are on ketogenic diets as it is known to increase ketone production thereby sparing lean muscle tissue. Ketogenesis (or the formation of ketones) becomes a major fuel factor on low carb (Atkins) diets as the brain cannot be driven by fatty acids and thereby relies on glucose first..and ketones second. So essentially, without Sesamin in your diet, the body will tap into muscle tissue for its ketone needs since carbohydrates are kept very low on Atkins or other prominent diets such as South Beach etc.

In Closing
Sesamin is an excellent addition for anybody’s workout regimen, not only to increase fat burning, but also for its overall anti-oxidant and nutrient partioning properties. Some of the later research†† even points out that Sesamin shows great promise in the lowering of LDL (bad) cholesterol while simultaneously increasing HDL (good) cholesterol levels in humans. **

PRODUCT HIGHLIGHTS!

Sesamin maximizes fat loss by increasing triglyceride (fat) oxidation.**
Sesamin supports insulin sensitivity and thus the partitioning of nutrients, especially protein into muscle cells.**
Sesamin increases the elevation of good (HDL) cholesterol.**
Sesamin supports liver health by metabolizing ethanol (alcohol).**
Sesamin protects the kidneys by recycling Vitamin E.**

**These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
† Some of these studies were performed on animals and not humans. Because of differences between humans and animals and the difficulty in determining the equivalence of dosages administered to animals and humans, the results of animal studies may not be transferable to humans.
†† These studies were performed at a different dosage than that in our product. The efficacy of this ingredient at the dosage level in our product has not been established in a clinical study and may not be equivalent.